Tom chases Jerry as usual from their house and across town until they arrive at the "International Space Place," where astronauts Buzz Blister and Biff Buzzard are heading to Mars. In the process, Tom and Jerry are caught during the speech (first misunderstood as aliens due to Tom getting hit by green paint backstage) and the staff try to capture them, but only Tom is caught and thrown out. During the testing of dehydrated food, Jerry knocks over a cup in the process, resulting in the food going all over the place in an explosion. Soon, the staff tries to catch Jerry, but figuring that only Tom can catch him, they bring him back to the base and give him a mission to eliminate Jerry. During the chase, the duo land onto a rocket, ending up at Mars, where Tom and Jerry are left behind. A green female alien named Peep along with an alien dog Ubu and three more Martians arrive, to which Jerry is then taken to the Martians' lair where he is mistaken for the "Great Gloop." After much calamity and a discovery that Jerry is not the Great Gloop, Tom, Jerry, and Peep hijack a flying saucer so that they can get back to Earth and warn everyone about a potential attack by the Martians. They manage to stop them, but a gigantic orange vacuum cleaner robot named the "Invince-a-tron" eventually arrives at Earth and begins to suck everyone up with its vacuum. Tom, Jerry, and Peep ultimately foil the Invince-a-tron by using a bone to get Spike into its brain and make it malfunction, destroying it. In the aftermath, Tom and Jerry are rewarded with a Hummer by the U.S. President for saving Earth from being destroyed by the Invince-a-tron. Before they could even drive it, however, they are attacked once again by a newly repaired Invince-a-tron controlled by Spike as revenge on Tom and Jerry for the destruction of his bone. Peep flies in the flying saucer and rescues Jerry, but leaves Tom behind to be chased by the Spike-controlled Invince-a-tron. In the epilogue, Biff and Buzz are cleaning the mess as punishment for lying that there is no life on Mars; they soon start to argue and fight about it as a horrified Tom is still being pursued by the Spike-controlled Invince-a-tron into the sunset.
According to Bill Kopp, the film's director and writer, the film was conceived and scripted in 2003 alongside Tom and Jerry: The Fast and the Furry; the film was announced by Business Wire on November 22, 2004. The film was animated by Toon City in Philippines.
The film received a negative review from Radio Times, which gave the film a two-star review and said "the characters are drawn a little too sharply, and the running time is just too long for the pacing that made the original shorts so perfect". Screen Rant has listed the film as one of the worst Tom and Jerry movies ever made, saying "The plot is fairly convoluted with the journey to and the journey from Mars feeling like they could have been made into two separate films which is likely why it received a lower score".
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