Production notes

On August 26, 2013, Universal Studios optioned an untitled script written by Amy Schumer that she would also star in. On November 27, 2013, it was announced that Judd Apatow would direct the film. On January 8, 2014, it was announced that the film would be released on July 24, 2015. On January 30, 2014, Bill Hader joined the cast of the film. On February 18, 2014, Brie Larson also joined the cast. On March 28, 2014, Colin Quinn, Barkhad Abdi, Mike Birbiglia, Jon Glaser, Vanessa Bayer, John Cena, Ezra Miller, and Tilda Swinton were cast in the film, though Abdi ultimately did not appear in it. On May 7, 2014, Method Man and LeBron James joined the cast of the film. On June 30, Daniel Radcliffe was spotted filming some scenes for the film, which confirmed his casting. On July 1, Marisa Tomei was also confirmed to appear, in scenes with Radcliffe. In an interview with The New York Times, Schumer revealed that she and Apatow dismissed their first idea for a story (later revealed to have Schumer as a used-car saleswoman), and shifted to an amplified and comedic version of Schumer's own past as its basis.

Principal photography began on May 19, 2014, in New York City. On June 2, the crew began filming in the area of Manhattan and Long Island. Principal photography ended on August 1, 2014. Editing on the movie began with the start of filming; the movie was finalized in December 2014.

Jon Brion composed the music for the film.

Trainwreck grossed $110.2 million in North America and $30.6 million in other territories for a total gross of $140.8 million, against a budget of $35 million. In the United States and Canada, Trainwreck opened on July 17, 2015, the same day as the superhero film Ant-Man. Initial projections had the film opening to around $20 million, with The Hollywood Reporter noting that it could overperform if it was popular with females or underperform given how R-rated comedies had struggled over the summer, with both Ted 2 and Magic Mike XXL failing to meet expectations. It made $1.8 million on Thursday night showings, which began at 8 p.m. in 2,363 theaters, and $10.7 million on its opening day. Through its opening weekend, it grossed $30.1 million in 3,158 theaters, exceeding expectations. This was Apatow's second-biggest debut as a director (just behind the $30.7 million debut of Knocked Up) and the sixth-biggest debut for a film that he was involved in as a writer, director or producer. The film played 69% female with 66% over 25 years old, which is typical for an R-rated comedy. According to a poll conducted by Rentrak in its opening weekend, 28% of respondents said they went to see the film because of Schumer.

On July 23, 2015, a mass shooting occurred at the Grand 16 movie theater in Lafayette, Louisiana, during a screening of the movie that resulted in two dead and nine injured.

On Rotten Tomatoes the film has an approval rating of 84% based on 286 reviews, with an average rating of 7.3/10. The website's critical consensus reads, "Trainwreck drags commitment out of all but the most rom-com-phobic filmgoers with sharp humor, relatable characters, and hilarious work from Amy Schumer." On Metacritic, the film has a weighted average score of 75 out of 100, based on 45 reviews, indicating "generally favorable reviews". Audiences polled by CinemaScore gave the film an average grade of "A−" on an A+ to F scale. Michael Phillips of the Chicago Tribune gave the film three and a half stars out of four, saying, "Schumer and Hader are wonderful together. Gender inequity in the world of comedy deserves all the overdue attention it's getting, and more. But there are matters of craft, wit (no matter how crude the jokes) and timing that transcend chromosomes." Richard Roeper of The Chicago Sun Times praised the performances of the cast, particularly Schumer, Hader, Quinn, and James. He also called Schumer's performance worthy of an Academy Award nomination. Benjamin Lee of The Guardian gave the film three out of five stars, stating, "Judd Apatow's latest is rough around the edges, but his focus on a female protagonist refreshes a genre in sore need of change". Ian Crouch, writing for The New Yorker, singled out LeBron James' performance for praise, writing that "it seems safe to declare that he has given the greatest motion-picture acting performance by an active professional basketball player of all time (but we know Jabbar already has this in Airplane)." Chris Nashawaty of Entertainment Weekly gave the film a B+, saying, "Beneath all of his bad-boy shtick, Apatow's always been a pretty conventional moralist. But Schumer gives their raunchy rom-com enough of her signature spikiness to prevent it from ever feeling predictable." Jacob Hall of the New York Daily News gave the film four out of five stars, saying, "Schumer raises Apatow's game beautifully. Her biting, pitch-black wit and his penchant for character-driven comedy go together like gin and tonic." Peter Travers of Rolling Stone gave the film three-and-a-half stars out of four, saying "Sweet is not how Schumer wants Trainwreck to go down. She wants to explode rom-com clichés and replace them with something fierce and ready to rumble. Done." Sara Stewart of the New York Post gave the film four out of four stars, saying "Trainwreck is a corrective to a lot of outdated clichés. It's very funny and sweet and even a little weepy, and it has maybe the best scene ever filmed of dirty talk gone wrong." Ty Burr of The Boston Globe gave the film three out of four stars, saying "Trainwreck serves as confirmation that a star is born, a seemingly average woman whose above-average superpowers include reminding us of our own. Where she goes from here should be fascinating to watch." Brian Truitt of USA Today gave the film three out of four stars, saying "With films such as Funny People and This Is 40, Apatow has toyed with finding the right blend of the serious and the hilarious and finally hits it here." Moira MacDonald of The Seattle Times gave the film three out of four stars, saying, "There's nothing remotely fresh about this plotline (or the way Apatow, true to form, makes the movie 20 minutes longer than it should be), but Trainwreck works as comedy more often than it doesn't—and that's rare enough." Alonso Duralde of The Wrap said, "Ultimately comes down in favor of mainstream girl-gets-boy in a way that Inside Amy Schumer might find a little dubious, but it never feels like Schumer is aggressively watering down her uniquely prickly brand of comedy for a mass audience."

Trainwreck was released on DVD and Blu-ray on November 10, 2015.