Production notes

Lionsgate and Crest Animation Productions announced the film on April 3, 2008 as the first film in a multi-picture partnership between the two parties. Anthony Bell and Ben Gluck would direct the film with the former making his feature directorial debut with the screenplay being written by Steve Moore and Christopher Denk, based on the former's original story with the voice cast being revealed around the same time. Lionsgate would distribute in the US and the UK while Mandate International, the international sales arm of Mandate Pictures would handle international sales, outside of India. Pre-production and post-production took place in Los Angeles, with key animation produced by Crest Animation Productions in India. The script was written in Toronto, Ontario, Canada.

Alpha and Omega took in $2,288,773 on its opening day, and $9,106,906 on its opening weekend domestically, reaching fifth place at the box office. The film ended its run on December 2, 2010 after grossing $25 million domestically and $25 million in other territories. It stands as Lionsgate's highest-grossing original animated film domestically, with eight follow-up sequels.

Alpha and Omega holds an approval rating of 20% on Rotten Tomatoes based on 57 reviews; the site's consensus is: "With bland visuals and a dull, predictable plot, Alpha and Omega is a runt in 2010's animated litter." At Metacritic, the film has a score of 36 out of 100 based on reviews from 15 critics, indicating "generally unfavorable" reviews. Andrew Barker of Variety gave the film a mixed review, writing: "Not without charm, Lionsgate's 3D animated pic is agreeably unambitious." Sheri Linden of The Hollywood Reporter wrote: "Abounding in dumb jokes that kids are bound to like but sometimes too scary for very young viewers, the movie -- also going out in 2D -- takes too long to find its footing and at best is proficient, not exhilarating."

Bernie Van De Yacht was nominated for an Artios Award for Outstanding Achievement in Casting.