Production notes

Principal photography and production began in London on October 21, 2013. Parts of the film were shot on location at Hedsor House in Buckinghamshire in the UK, where Depp, Munn, and Bettany filmed scenes in Hedsor House's Boudoir and Bridal Suites. Scenes were also shot on location at the National Art Library in the Victoria and Albert Museum in London. The Goya painting is a pastiche or modern version of the 1805 Portrait of the Marchioness of Santa Cruz (Madrid, Prado Museum).

Mortdecai grossed $7.7 million in North America and $39.6 million in other territories for a worldwide total of $47.3 million, against a production budget of $60 million. The film was released in North America on January 23, 2015. The film was projected to gross around $10 million from 2,648 theaters in its opening weekend. The film made $1.5 million its first day and went on to gross $4.2 million in its opening weekend, finishing 9th at the box office. In its third week the film was pulled from 2,395 theaters (a 90.4% drop), the 10th biggest theater drop in history at the time.

On Rotten Tomatoes, Mortdecai has an approval rating of 12% based on 110 reviews and an average rating of 3.4/10, making it the lowest-rated film produced by OddLot Entertainment to date. The site's critical consensus reads: "Aggressively strange and willfully unfunny, the misguided Mortdecai sounds a frightfully low note in Johnny Depp's post-Pirates filmography". On Metacritic, the film has a score of 27 out of 100, based on 21 critics, indicating "generally unfavorable reviews". Audiences polled by CinemaScore gave the film an average grade of "C+" on an A+ to F scale. On Twitter, Robbie Collin of The Daily Telegraph characterised the film as "The Crap Budapest Hotel", elaborating in his review: "Mortdecai: mort de cinéma, more like". Christopher Rosen of The Huffington Post said that Mortdecai "seems destined to be rated as the worst film of 2015, and deservedly so". Reviewing the film in The Guardian, Mark Kermode gave it 1 star out of 5, describing it as "a dismally unfunny comic thriller with only one decent joke". In a negative review for The New York Times, Stephen Holden described the film as "a frantically dull spectacle". Later, in February 2022, director David Koepp took partial blame for the films' failure: "I only directed something someone else wrote once and it was a misbegotten adventure from the beginning, as much my fault as anybody else’s."